The Open Targets team at our 10 year anniversary celebration in October 2024
Join our team!
Open Targets is based on the stunning Wellcome Genome Campus, home to some of the world's foremost institutes and organisations in genomics and computational biology. We work in dynamic teams at the interface of academic and pharma industry science on a crucial problem, how to be more successful in making drugs. Working with us, you will be exposed to new technologies and a dynamic set of scientists dedicated to translational research.
Our posts are usually in either one of our academic partners, The Wellcome Sanger Institute or EMBL-EBI and have terms and conditions associated with the employer.
Important note: applications may be reviewed on an ongoing basis and the advertised post(s) may be filled before the stated deadline.
Postdoc in CRISPR Meta-Analytics and AI for Therapeutic Target Discovery and Priotisation (Perturbation Catalogue Project)
Application closing date: 5 October 2025
Play a key role in the Open Targets Perturbation Catalogue Project, which aims to create an online repository of data from functional genetics screens and, more generally, post-perturbational experiments (typically CRISPR screens with viability or transcriptomics readouts). We will focus on a specific meta-analytics work package, developing computational methods for the reproducibility assessment, harmonisation and analysis of inter-study CRISPR datasets, aggregating data and developing and using innovative AI based-methods for therapeutic target prioritisation pipelines3 on the resulting aggregated data for cancer, neurodegenerative disorders and other diseases.